Article
Role of P-glycoprotein in dolastatin 10 resistance.
Biochemical pharmacology - 3 Aug 1994
Toppmeyer D L, Slapak C A, Croop J, Kufe D W
Abstract excerpt
Dolastatin 10, a cytotoxic pentapeptide isolated from the mollusk Dolabella auricularia, exhibits potent antitumor activity. The present studies demonstrated that sublines of murine PC4 and human U-937 leukemia cells expressing a multidrug resistance (MDR) phenotype are cross-resistant to this ag...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Animals
- Antineoplastic Agents
- Carrier Proteins
- Cell Line
- Cricetinae
- Depsipeptides
- Drug Resistance
- Humans
- Membrane Glycoproteins
- Mice
- Oligopeptides
- Phenotype
- Transfection
- Verapamil