Article
Functional evidence that transmembrane 12 and the loop between transmembrane 11 and 12 form part of the drug-binding domain in P-glycoprotein encoded by MDR1.
The Journal of biological chemistry - 10 Mar 1995
Zhang X, Collins K I, Greenberger L M
Abstract excerpt
Human MDR1 encodes an ATP-binding cassette transporter, P-glycoprotein, that mediates multiple drug resistance (MDR) to antitumor agents. It has been previously shown that photoaffinity drug-labeling sites reside within, or near, the last transmembrane loop of each cassette within P-glycoprotein...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Affinity Labels
- Amino Acid Sequence
- Azides
- Binding Sites
- Cell Line
- Cisplatin
- Colchicine
- Dactinomycin
- Doxorubicin
- Drug Resistance, Multiple
- Humans
- Iodine Radioisotopes
- Melanoma
- Molecular Sequence Data
- Phenotype
- Prazosin
- Protein Structure, Secondary