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Article

Multidrug resistance phenotype associated with selection of an aminopterin resistant dog kidney cell line.

Pharmacogenetics - 1 Dec 1991

Turker M S, Duffin K Z, Smith A C, Martin G M, Martin A W, DiMartino D L, Kersey D S

Abstract excerpt

A determination of the mechanisms of drug resistance in tumour cells is important for developing strategies to combat such resistance in persons receiving chemotherapy. This report describes a combined cellular, biochemical, and molecular analysis of a dog kidney cell line selected for resistance to increasing levels of the hydrophilic antifolate, aminopterin. Three distinct drug resistance phenotypes were...

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Identifiers

PMID: 1688246
DOI: 10.1097/00008571-199112000-00005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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