Article
Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.
Journal of the National Cancer Institute - 1 Aug 1990
McLachlin J R, Eglitis M A, Ueda K, Kantoff P W, Pastan I H, Anderson W F, Gottesman M M
Abstract excerpt
In multidrug resistance, cells become simultaneously resistant to anthracyclines, vinca alkaloids, epipodophyllotoxins, and certain other natural product cytotoxic drugs. Resistance results from synthesis of a multidrug transporter (P-glycoprotein) encoded by the MDR1 gene (also known as the PGY1...
Topics
- Animals
- Bone Marrow
- Bone Marrow Cells
- Cells, Cultured
- Clone Cells
- Colchicine
- DNA
- Drug Resistance
- Gene Expression
- Genes, Viral
- Harvey murine sarcoma virus
- Hematopoietic Stem Cells
- Humans
- Methylcellulose
- Mice
- Phenotype
- Retroviridae
- Transcription, Genetic