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Article

Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias.

Haematologica - 1 Apr 2007

Falini Brunangelo, Nicoletti Ildo, Bolli Niccolò, Martelli Maria Paola, Liso Arcangelo, Gorello Paolo, Mandelli Franco, Mecucci Cristina, Martelli Massimo Fabrizio

Abstract excerpt

Nucleophosmin (NPM) is a ubiquitously expressed nucleolar phoshoprotein which shuttles continuously between the nucleus and cytoplasm. Many findings have revealed a complex scenario of NPM functions and interactions, pointing to proliferative and growth-suppressive roles of this molecule. The gene NPM1 that encodes for nucleophosmin (NPM1) is translocated or mutated in various lymphomas and leukemias, forming...

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Share to Chromosomes, Human, Pair 5

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leukemia, Myeloid

Share to Lymphoma, Large-Cell, Anaplastic

Share to Nucleophosmin

Share to Oncogene Proteins, Fusion

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Share to Translocation, Genetic

Source

Identifiers

PMID: 17488663
DOI: 10.3324/haematol.11007

Genes

NPM1
ALK
FLT3
MLF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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