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Article

Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.

Pharmacogenomics - 1 Sept 2009

Janha Ramatoulie E, Sisay-Joof Fatoumatta, Hamid-Adiamoh Majidah, Worwui Archibald, Chapman Hannah L, Opara Hyginus, Dunyo Sam, Milligan Paul, Rockett Kirk, Winstanley Peter, Pirmohamed Munir, Miller Ann K, Conway David J, Walton Robert T

Abstract excerpt

AIMS: Antimalarial biguanides are metabolized by CYP2C19, thus genetic variation at the CYP2C locus might affect pharmacokinetics and so treatment outcome for malaria. MATERIALS & METHODS: Polymorphisms in CYP2C19 and CYP2C9 in 43 adult Gambians treated with chlorproguanil/dapsone for uncomplicated malaria were assessed. Chlorcycloguanil pharmacokinetics were measured and associations with CYP2C19 and CYP2C9...

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Identifiers

PMID: 19761366
DOI: 10.2217/pgs.09.72
PMCID: PMC3870622

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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