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Article

Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia.

Pharmacogenetics - 1 Nov 2003

Masta Andrew, Lum J Koji, Tsukahara Takahiro, Hwaihwanje Ilomo, Kaneko Akira, Paniu Michael M, Sapuri Mathias, Takahashi Nobuyuki, Ishizaki Takashi, Kobayakawa Takatoshi, Hombhanje Francis W

Abstract excerpt

The cytochrome P450 (CYP) isozyme CYP2C19 metabolizes clinically important drugs, including the anti-malarial proguanil currently used for multi-drug resistant Plasmodium falciparum malaria. CYP2C19 activity varies among geographical regions due to high frequencies of two null alleles (CYP2C19*2/*3) in Asian and especially Pacific populations. Previously, we reported an unprecedentedly high frequency of CYP2C19...

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Identifiers

PMID: 14583683
DOI: 10.1097/00008571-200311000-00006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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