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Article

Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia.

PloS one - 1 Jan 2011

Dunyo Samuel, Sirugo Giorgio, Sesay Sanie, Bisseye Cyrille, Njie Fanta, Adiamoh Majidah, Nwakanma Davis, Diatta Mathurin, Janha Ramatoulie, Sisay Joof Fatou, Temple Beth, Snell Paul, Conway David, Walton Robert, Cheung Yin Bun, Milligan Paul

Abstract excerpt

BACKGROUND: Chlorproguanil-dapsone (Lapdap), developed as a low-cost antimalarial, was withdrawn in 2008 after concerns about safety in G6PD deficient patients. This trial was conducted in 2004 to evaluate the safety and effectiveness of CD and comparison with artemether-lumefantrine (AL) under conditions of routine use in G6PD normal and G6PD deficient patients with uncomplicated malaria in The Gambia. We also...

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Identifiers

PMID: 21666744
DOI: 10.1371/journal.pone.0017371
PMCID: PMC3110183

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