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Article

MicroRNA-449a deficiency promotes colon carcinogenesis.

Scientific reports - 6 Sept 2017

Niki Masanori, Nakajima Kohei, Ishikawa Daichi, Nishida Jun, Ishifune Chieko, Tsukumo Shin-Ichi, Shimada Mitsuo, Nagahiro Shinji, Mitamura Yoshinori, Yasutomo Koji

Abstract excerpt

MicroRNAs have broad roles in tumorigenesis and cell differentiation through regulation of target genes. Notch signaling also controls cell differentiation and tumorigenesis. However, the mechanisms through which Notch mediates microRNA expression are still unclear. In this study, we aimed to identify microRNAs regulated by Notch signaling. Our analysis found that microRNA-449a (miR-449a) was indirectly regulated...

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Share to Cell Transformation, Neoplastic
Share to Colonic Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Immunophenotyping

Share to MicroRNAs

Share to MutL Protein Homolog 1

Share to Receptors, Notch

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Source

Open in PubMed Open full text

Identifiers

PMID: 28878284
DOI: 10.1038/s41598-017-10500-0
PMCID: PMC5587792

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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