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Article

Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.

Cancer research - 1 Oct 2001

Sansom O J, Stark L A, Dunlop M G, Clarke A R

Abstract excerpt

Numerous studies have indicated that exposure to nonsteroidal anti-inflammatory drugs is associated with a lowered risk of colorectal cancer. However, analyses of the effect of aspirin upon tumorigenesis in Apc(Min/+) mice have yielded contrasting results. We show that adult dietary exposure to aspirin does not suppress intestinal tumorigenesis in Apc(Min/+) mice, but that continual exposure from the point of...

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Share to Anti-Inflammatory Agents, Non-Steroidal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, APC

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Share to Mammary Neoplasms, Experimental

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Share to Prenatal Exposure Delayed Effects

Source

Identifiers

PMID: 11585736

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of intestinal and mammary neoplasia by lifetime administration of aspirin in Apc(Min/+) and Apc(Min/+), Msh2(-/-) mice.PMID 11585736Read ↗

Age-related difference in susceptibility of Apc(Min/+) mice towards the chemopreventive efficacy of dietary aspirin and curcumin.Semantic proximity Read ↗

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Impact of Dnmt1 deficiency, with and without low folate diets, on tumor numbers and DNA methylation in Min mice.Semantic proximity Read ↗

Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins.Semantic proximity Read ↗

Somatic Apc mutations are selected upon their capacity to inactivate the beta-catenin downregulating activity.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.Semantic proximity Read ↗

Sulindac effects on inflammation and tumorigenesis in the intestine of mice with Apc and Mlh1 mutations.Semantic proximity Read ↗

A knock-in mouse model reveals roles for nuclear Apc in cell proliferation, Wnt signal inhibition and tumor suppression.Semantic proximity Read ↗

Dysregulated expression of beta-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice.Semantic proximity Read ↗

Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the Apc(Min/+) mouse.Semantic proximity Read ↗

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