Article
MTHFR genotype and colorectal adenoma recurrence: data from a double-blind placebo-controlled clinical trial.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 2008
Levine A Joan, Wallace Kristin, Tsang Shirley, Haile Robert W, Saibil Fred, Ahnen Dennis, Cole Bernard F, Barry Elizabeth L, Munroe David J, Ali Iqbal U, Ueland Per, Baron John A
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. We assessed the association between two common MTHFR variants, 677C>T and 1298A>C, and adenoma recurrence in the context of a randomized double- blind clinical trial of aspirin use and folate supplementation. We used generalized linear regression to estimate risk ratios and 95% confidence intervals (95% CI) for recurrence, adjusting...
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