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Article

COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations.

Cancer causes & control : CCC - 1 Dec 2013

Makar Karen W, Poole Elizabeth M, Resler Alexa J, Seufert Brenna, Curtin Karen, Kleinstein Sarah E, Duggan David, Kulmacz Richard J, Hsu Li, Whitton John, Carlson Christopher S, Rimorin Christine F, Caan Bette J, Baron John A, Potter John D, Slattery Martha L, Ulrich Cornelia M

Abstract excerpt

PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) target the prostaglandin H synthase enzymes, cyclooxygenase (COX)-1 and COX-2, and reduce colorectal cancer risk. Genetic variation in the genes encoding these enzymes may be associated with changes in colon and rectal cancer risk and in NSAID efficacy. METHODS: We genotyped candidate polymorphisms and tag SNPs in PTGS1 (COX-1) and PTGS2 (COX-2) in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24022467
DOI: 10.1007/s10552-013-0282-1
PMCID: PMC3913564

Genes

PTGS1
PTGS2

Provenance

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