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Article

Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars.

Biochemistry - 13 Oct 2009

Reynolds C Michael, Raetz Christian R H

Abstract excerpt

Escherichia coli mutants deficient in 2-keto-3-deoxy-D-manno-octulosonic acid (Kdo) biosynthesis are conditionally lethal, but their phenotypes are bypassed by certain suppressor mutations or by overexpression of MsbA, the inner membrane flippase for core-lipid A. These strains grow on broth with the tetraacylated precursor lipid IV(A) replacing lipopolysaccharide [Meredith, T. C., et al. (2006) ACS Chem. Biol....

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Identifiers

PMID: 19754149
DOI: 10.1021/bi901391g
PMCID: PMC2782650

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