Article
Mutations in enterobacterial common antigen biosynthesis restore outer membrane barrier function in Escherichia coli tol-pal mutants.
Molecular microbiology - 1 Dec 2020
Jiang Xiang'Er, Tan Wee Boon, Shrivastava Rahul, Seow Deborah Chwee San, Chen Swaine Lin, Guan Xue Li, Chng Shu-Sin
Abstract excerpt
The outer membrane (OM) is an essential component of the Gram-negative bacterial envelope that protects the cells against external threats. To maintain a functional OM, cells require distinct mechanisms to ensure balance of proteins and lipids in the membrane. Mutations in OM biogenesis and/or homeostasis pathways often result in permeability defects, but how molecular changes in the OM affect barrier function is...
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