Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli.

doi:10.1074/jbc.270.46.27646

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Article

Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli.

The Journal of biological chemistry - 17 Nov 1995

Belunis C J, Clementz T, Carty S M, Raetz C R

Abstract excerpt

The enzyme 3-deoxy-D-manno-octulosonic acid (Kdo) transferase is encoded by the kdtA gene in Escherichia coli. The enzyme is a single polypeptide that catalyzes the transfer of two Kdo residues to a tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A, designated lipid IVA (Belunis, C.J., and Raetz, C.R.H. (1992) J. Biol. Chem. 267, 9988-9997). To determine if Kdo transfer to lipid IVA is required for...

Topics

Carbohydrate Conformation
Carbohydrate Sequence
Chromosomes, Bacterial
Escherichia coli
Genes, Bacterial
Genetic Complementation Test
Genotype
Kinetics
Lipopolysaccharides
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis, Insertional

Plasmids

Salmonella typhimurium

Species Specificity

Temperature

Time Factors

Transferases

Source

Open in PubMed

Identifiers

PMID: 7499229
DOI: 10.1074/jbc.270.46.27646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7499229-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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