Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruptions in outer membrane-peptidoglycan interactions enhance bile salt resistance in O-antigen-producing E. coli.

mBio - 8 Oct 2025

Qin Jilong, Hong Yaoqin, Vollmer Waldemar, Morona Renato, Totsika Makrina

Abstract excerpt

Bile salts (BS) are antimicrobials that disrupt bacterial cell membranes and induce oxidative stress. The gut bacterium Escherichia coli is naturally resistant to BS, including the model strain K12 MG1655 that produces a lipopolysaccharide (LPS) without O-antigen (OAg) on the cell surface. Paradoxically, we have previously shown that restoring a wild-type like LPS with attached OAg (MG1655-S) sensitizes E. coli...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Bile Acids and Salts

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

Share to Escherichia coli K12

Share to Escherichia coli Proteins

Share to Lipopolysaccharides

Share to O Antigens

Share to Peptidoglycan

Source

Open in PubMed Open full text

Identifiers

PMID: 40874615
DOI: 10.1128/mbio.02184-25
PMCID: PMC12505904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruptions in outer membrane-peptidoglycan interactions enhance bile salt resistance in O-antigen-producing E. coli.PMID 40874615Read ↗

Disruptions in Outer Membrane-Peptidoglycan Interactions Enhance Bile Salt Resistance in O-antigen-Producing <i>E. coli</i>Semantic proximity Read ↗

A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface.Semantic proximity Read ↗

Synergy between Group 2 capsules and lipopolysaccharide underpins serum resistance in extra-intestinal pathogenic Escherichia coli.Semantic proximity Read ↗

Mutations in enterobacterial common antigen biosynthesis restore outer membrane barrier function in Escherichia coli tol-pal mutants.Semantic proximity Read ↗

Phenotypic and multi-omics characterization of <i>Escherichia coli</i> K-12 adapted to quaternary ammonium compounds identifies lipid A and cell envelope alterations regulated by mar-sox-rob and stress inducible pathwaysSemantic proximity Read ↗

Outer membrane biogenesis in Escherichia coli, Neisseria meningitidis, and Helicobacter pylori: paradigm deviations in H. pyloriSemantic proximity Read ↗

Escherichia coli K-12 Suppressor-free Mutants Lacking Early Glycosyltransferases and Late Acyltransferases: minimal lipopolysaccharide structure and induction of envelope stress response.Semantic proximity Read ↗

Analysis of Shigella flexneri Resistance, Biofilm Formation, and Transcriptional Profile in Response to Bile Salts.Semantic proximity Read ↗

PBP1A and LdtJ support cell envelope homeostasis and impact selection of Colistin-resistance in <i>Acinetobacter baumannii</i>Semantic proximity Read ↗

Biosynthesis and structure of the Burkholderia cenocepacia K56-2 lipopolysaccharide core oligosaccharide: truncation of the core oligosaccharide leads to increased binding and sensitivity to polymyxin B.Semantic proximity Read ↗

High-level carbapenem tolerance requires antibiotic-induced outer membrane modificationsSemantic proximity Read ↗

A Molecular Link between Cell Wall Modification and Stringent Response in a Gram-positive BacteriaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.