Article
Periplasmic orientation of nascent lipid A in the inner membrane of an Escherichia coli LptA mutant.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2008
Ma Bing, Reynolds C Michael, Raetz Christian R H
Abstract excerpt
The core-lipid A domain of Escherichia coli lipopolysaccharide (LPS) is synthesized on the inner surface of the inner membrane (IM) and flipped to its outer surface by the ABC transporter MsbA. Recent studies with deletion mutants implicate the periplasmic protein LptA, the cytosolic protein LptB, and the IM proteins LptC, LptF, and LptG in the subsequent transport of nascent LPS to the outer membrane (OM), where...
Topics
- Biological Transport
- Carrier Proteins
- Cell Membrane
- Escherichia coli
- Escherichia coli Proteins
- Lipid A
- Lipopolysaccharides
- Microbial Viability
- Models, Molecular
- Mutation
- Periplasm