Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides.

Marine drugs - 31 Jan 2013

Han Yaning, Li Ye, Chen Jiuzhou, Tan Yanzhen, Guan Feng, Wang Xiaoyuan

Abstract excerpt

The lipid A moiety of Escherichia coli lipopolysaccharide is a hexaacylated disaccharide of glucosamine phosphorylated at the 1- and 4'-positions. It can be recognized by the TLR4/MD-2 complex of mammalian immune cells, leading to release of proinflammatory cytokines. The toxicity of lipid A depends on its structure. In this study, two E. coli mutants, HW001 and HW002, were constructed by deleting or integrating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Escherichia coli

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Lipid A

Share to Lipopolysaccharides

Share to Macrophages, Peritoneal

Share to Plasmids

Source

Open in PubMed Open full text

Identifiers

PMID: 23434832
DOI: 10.3390/md11020363
PMCID: PMC3640385

Genes

TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Construction of monophosphoryl lipid A producing Escherichia coli mutants and comparison of immuno-stimulatory activities of their lipopolysaccharides.PMID 23434832Read ↗

Construction and characterization of an Escherichia coli mutant producing Kdo₂-lipid A.Semantic proximity Read ↗

Construction of Escherichia coli Mutant with Decreased Endotoxic Activity by Modifying Lipid A Structure.Semantic proximity Read ↗

Distinct biological activity of lipopolysaccharides with different lipid A acylation status from mutant strains of Yersinia pestis and some members of genus Psychrobacter.Semantic proximity Read ↗

Lipopolysaccharide engineering in Neisseria meningitidis: structural analysis of different pentaacyl lipid A mutants and comparison of their modified agonist properties.Semantic proximity Read ↗

Replacement of lipopolysaccharide with free lipid A molecules in Escherichia coli mutants lacking all core sugars.Semantic proximity Read ↗

Site-specific acylation changes in the lipid A of Escherichia coli lpxL mutants grown at high temperatures.Semantic proximity Read ↗

Lack of Lipid A Pyrophosphorylation and Functional <i>lptA</i> Reduces Inflammation by Neisseria CommensalsSemantic proximity Read ↗

Effects of lipid A acyltransferases on the pathogenesis of F. novicida.Semantic proximity Read ↗

Evolution of the Kdo2-lipid A biosynthesis in bacteriaSemantic proximity Read ↗

Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function.Semantic proximity Read ↗

The enzymatic synthesis of lipid A: molecular structure and biologic function of monosaccharide precursors.Semantic proximity Read ↗

Engineering low-endotoxin lipid A in a double auxotroph Pseudomonas aeruginosa to develop safer whole-cell vaccines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.