Article
Increased activation ability of monocytes from ALS patients.
Experimental neurology - 1 Jun 2020
Du Yunlan, Zhao Weihua, Thonhoff Jason R, Wang Jinghong, Wen Shixiang, Appel Stanley H
Abstract excerpt
Neuroinflammation is increasingly recognized as an important mediator of disease progression in patients with amyotrophic lateral sclerosis (ALS). Recent research suggests that pro-inflammatory microglia in ALS mice promote motoneuron cytotoxicity by secreting reactive oxygen species and pro-inflammatory cytokines. Gene expression analyses indicate that peripheral circulating monocytes from ALS patients are...
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