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Article

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 20 Jan 2016

Gravel Mathieu, Béland Louis-Charles, Soucy Geneviève, Abdelhamid Essam, Rahimian Reza, Gravel Claude, Kriz Jasna

Abstract excerpt

While reactive microgliosis is a hallmark of advanced stages of amyotrophic lateral sclerosis (ALS), the role of microglial cells in events initiating and/or precipitating disease onset is largely unknown. Here we provide novel in vivo evidence of a distinct adaptive shift in functional microglial phenotypes in preclinical stages of superoxide dismutase 1 (SOD1)-mutant-mediated disease. Using a mouse model for...

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Source

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Identifiers

PMID: 26791230
DOI: 10.1523/JNEUROSCI.0854-15.2016
PMCID: PMC6601999

Genes

SOD1
TLR2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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