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Article

A pre-S gene chip to detect pre-S deletions in hepatitis B virus large surface antigen as a predictive marker for hepatoma risk in chronic hepatitis B virus carriers.

Journal of biomedical science - 15 Sept 2009

Shen Fan-Ching, Su Ih-Jen, Wu Han-Chieh, Hsieh Yi-Hsuan, Yao Wei-Jen, Young Kung-Chia, Chang Tsung-Chuan, Hsieh Hui-Chuan, Tsai Han-Ni, Huang Wenya

Abstract excerpt

BACKGROUND: Chronic hepatitis B virus (HBV) infection is an important cause of hepatocellular carcinoma (HCC) worldwide. The pre-S1 and -S2 mutant large HBV surface antigen (LHBS), in which the pre-S1 and -S2 regions of the LHBS gene are partially deleted, are highly associated with HBV-related HCC. METHODS: The pre-S region of the LHBS gene in two hundred and one HBV-positive serum samples was PCR-amplified and...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19751529
DOI: 10.1186/1423-0127-16-84
PMCID: PMC2755474

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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