Article
Association of hepatitis B virus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B.
The Journal of infectious diseases - 1 Mar 2011
Yeung Pok, Wong Danny Ka-Ho, Lai Ching-Lung, Fung James, Seto Wai-Kay, Yuen Man-Fung
Abstract excerpt
BACKGROUND: We aimed to determine whether hepatitis B virus (HBV) pre-S deletion was an independent factor for the development of hepatocellular carcinoma (HCC). METHODS: Pre-S deletions were determined in HBV isolates from 115 chronic hepatitis B (CHB) patients with HCC. Sixty-nine patients were further matched with 69 CHB patients without HCC for age, sex, hepatitis B e antigen (HBeAg) status, and HBV genotype....
Topics
- Adult
- Aged
- Amino Acid Sequence
- Carcinoma, Hepatocellular
- Case-Control Studies
- DNA Primers
- Databases, Nucleic Acid
- Female
- Gene Deletion
- Genotype
- Hepatitis B Surface Antigens
- Hepatitis B virus
- Hepatitis B, Chronic