Article
Differential processing and turnover of the oncogenically activated neu/erb B2 gene product and its normal cellular counterpart.
The Journal of biological chemistry - 25 Feb 1990
Huang S S, Koh H A, Konish Y, Bullock L D, Huang J S
Abstract excerpt
In nontransformed DHFR/G-8 cells (NIH 3T3 cells transfected with normal rat neu gene), the normal neu gene product was initially synthesized as a 170-kDa protein bearing endoglycosidase H-sensitive oligosaccharide chains and was then processed to a 175-kDa mature form with endoglycosidase H-resis...
Topics
- Amino Acid Sequence
- Ammonium Chloride
- Animals
- Cells, Cultured
- Gene Expression Regulation
- Glycoside Hydrolases
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein-Tyrosine Kinases