Article
Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation.
Oncogene - 13 Feb 1997
Burke C L, Lemmon M A, Coren B A, Engelman D M, Stern D F
Abstract excerpt
The neu proto-oncogene encodes a receptor tyrosine kinase (RTK). The oncogenic allele neu* (p185*) bears a glutamic acid for valine substitution at position 664 within the predicted transmembrane domain. We have used this mutant to explore the role of the transmembrane domain in signal transducti...
Topics
- 3T3 Cells
- Amino Acid Sequence
- Animals
- Binding Sites
- COS Cells
- Dimerization
- Glycophorins
- Mice
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Structure, Secondary
- Receptor, ErbB-2
- Recombinant Fusion Proteins
- Sequence Homology, Amino Acid
- Signal Transduction
- Transformation, Genetic
- Tyrosine