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Article

Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation.

Oncogene - 13 Feb 1997

Burke C L, Lemmon M A, Coren B A, Engelman D M, Stern D F

Abstract excerpt

The neu proto-oncogene encodes a receptor tyrosine kinase (RTK). The oncogenic allele neu* (p185*) bears a glutamic acid for valine substitution at position 664 within the predicted transmembrane domain. We have used this mutant to explore the role of the transmembrane domain in signal transduction by RTKs. Analysis of a panel of neu* proteins with second-site mutations in the transmembrane domain revealed a...

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Source

Identifiers

PMID: 9038376
DOI: 10.1038/sj.onc.1200873

Genes

EGF
EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Dimerization of the p185neu transmembrane domain is necessary but not sufficient for transformation.PMID 9038376Read ↗

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