Article
Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.
Genome biology - 1 Jan 2009
Bivi Nicoletta, Romanello Milena, Harrison Richard, Clarke Ian, Hoyle David C, Moro Luigi, Ortolani Fulvia, Bonetti Antonella, Quadrifoglio Franco, Tell Gianluca, Delneri Daniela
Abstract excerpt
BACKGROUND: Nitrogen-containing bisphosphonates are the elected drugs for the treatment of diseases in which excessive bone resorption occurs, for example, osteoporosis and cancer-induced bone diseases. The only known target of nitrogen-containing bisphosphonates is farnesyl pyrophosphate synthase, which ensures prenylation of prosurvival proteins, such as Ras. However, it is likely that the action of...
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