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Article

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast.

Nature - 11 Nov 2010

Pavelka Norman, Rancati Giulia, Zhu Jin, Bradford William D, Saraf Anita, Florens Laurence, Sanderson Brian W, Hattem Gaye L, Li Rong

Abstract excerpt

Aneuploidy, referring here to genome contents characterized by abnormal numbers of chromosomes, has been associated with developmental defects, cancer and adaptive evolution in experimental organisms. However, it remains unresolved how aneuploidy impacts gene expression and whether aneuploidy could directly bring about phenotypic variation and improved fitness over that of euploid counterparts. Here we show,...

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Identifiers

PMID: 20962780
DOI: 10.1038/nature09529
PMCID: PMC2978756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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