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Article

Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae.

Biochimica et biophysica acta - 1 Dec 2010

Huang Xiaobin, Morse Leslie R, Xu Yan, Zahradka Jaromir, Sychrová Hana, Stashenko Phil, Fan Feiyue, Battaglino Ricardo A

Abstract excerpt

BACKGROUND: NHAoc/NHA2 is highly and selectively expressed in osteoclasts and plays a role(s) in normal osteoclast differentiation, apoptosis and bone resorptive function in vitro. Extensive mutational analysis of a bacterial homologue, NhaA, has revealed a number of amino acid residues essential for its activity. Some of these residues are evolutionarily conserved and have been shown to be essential not only for...

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Identifiers

PMID: 20713131
DOI: 10.1016/j.bbagen.2010.08.001
PMCID: PMC2967667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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