Article
Robust detection of EGFR copy number changes and EGFR variant III: technical aspects and relevance for glioma diagnostics.
Brain pathology (Zurich, Switzerland) - 1 Oct 2009
Jeuken Judith, Sijben Angelique, Alenda Cristina, Rijntjes Jos, Dekkers Marieke, Boots-Sprenger Sandra, McLendon Roger, Wesseling Pieter
Abstract excerpt
Epidermal growth factor receptor (EGFR) is commonly affected in cancer, generally in the form of an increase in DNA copy number and/or as mutation variants [e.g., EGFR variant III (EGFRvIII), an in-frame deletion of exons 2-7]. While detection of EGFR aberrations can be expected to be relevant for glioma patients, such analysis has not yet been implemented in a routine setting, also because feasible and robust...
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