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Article

An overview of the epidermal growth factor receptor fluorescence in situ hybridisation challenge in tumour pathology

3 Dec 2008

Abstract excerpt

Epidermal growth factor receptor (EGFR) is deregulated in a variety of solid malignant tumours. Due to the availability of specific targeted therapies, the request to evaluate EGFR in neoplastic tissues in pathology is dramatically increasing. In analogy to HER2, EGFR evaluation by FISH seems to be superior than immunohistochemistry to select patients for targeted therapies. However, the lack of consensus on how...

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PMID: 19052028
DOI: 10.1136/jcp.2008.059592

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