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Article

Targeted disruption of stat3 reveals a major role for follicular stem cells in skin tumor initiation.

Cancer research - 1 Oct 2009

Kim Dae Joon, Kataoka Ken, Rao Dharanija, Kiguchi Kaoru, Cotsarelis George, Digiovanni John

Abstract excerpt

The initiation stage of mouse skin carcinogenesis involves the induction of mutations in keratinocyte stem cells (KSC), which confers a selective growth advantage allowing clonal expansion during tumor promotion. Targeted disruption of signal transducer and activator of transcription 3 (Stat3) in bulge region KSCs was achieved by treating K15.CrePR1 x Stat3(fl/fl) mice with RU486. Deletion of Stat3 prior to skin...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19738054
DOI: 10.1158/0008-5472.CAN-09-1180
PMCID: PMC4043290

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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