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Article

Stat3 is required for the development of skin cancer

1 Sept 2004

Abstract excerpt

Signal transducer and activator of transcription 3 (Stat3) is a transcription factor that is constitutively activated in a variety of human malignancies, including prostate, lung, brain, breast, and squamous cell carcinomas. Inhibition of activated Stat3 leads to decreased proliferation and apoptosis of many cancer-derived cell lines, while the introduction of a constitutively activated form of Stat3 into...

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PMID: 15343379
DOI: 10.1172/jci22800

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