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Article

Chemically induced skin tumors arise from long-lived stem cells of the upper hair follicle.

Science (New York, N.Y.) - 6 Aug 2026

Kandyba Eve, Jabouille Arnaud, Calvet Ferriol, Li Yun Rose, Curtabbi Andrea, Cristea Diana, Shin Joyce, Delrosario Reyno, Anzules Jonathan, Wu Di, Quigley David, Taylor Mark, Zanette Camila, Lo Fang Yin, Higgins Jacob, Salk Jesse, Lopez-Bigas Nuria, Balmain Allan

Abstract excerpt

The identification of the cancer cell of origin is a fundamental issue in cancer biology. We used fluorescent lineage tracing of independent mouse skin stem cell populations, single-cell transcriptomics, and duplex sequencing to identify the origin of chemically induced skin tumors. Tumors arose predominantly from Lgr6+ and/or Lrig1+ stem cells of the upper hair follicle but only very rarely from the Lgr5+ and...

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Share to 9,10-Dimethyl-1,2-benzanthracene
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, ras

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Share to Neoplasms, Experimental

Share to Receptors, G-Protein-Coupled

Source

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Identifiers

PMID: 42275467
DOI: 10.1126/science.adv8291
PMCID: PMC13459747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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