Article

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

2004-09-01

Abstract excerpt

Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter 12-O-tetr...

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Literature Corpus work: f0e1a0e9-a594-5950-a32d-5075041841e6
DOI: 10.1172/jci200421032

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