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Article

Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis.

The Journal of investigative dermatology - 1 Sept 2011

Cianfarani Francesca, Bernardini Silvia, De Luca Naomi, Dellambra Elena, Tatangelo Laura, Tiveron Cecilia, Niessen Carien M, Zambruno Giovanna, Castiglia Daniele, Odorisio Teresa

Abstract excerpt

The 14-3-3 protein family controls diverse biochemical processes through interaction with phosphorylated consensus sequences in protein targets. Its epithelial specific member, 14-3-3σ, also known as stratifin, is highly expressed in differentiated keratinocytes, and in vitro evidence indicates that 14-3-3σ downregulation leads to keratinocyte immortalization. To define the role of 14-3-3σ in skin homeostasis in...

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Identifiers

PMID: 21654836
DOI: 10.1038/jid.2011.137

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