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Article

Disruption of Smad4 in mouse epidermis leads to depletion of follicle stem cells.

Molecular biology of the cell - 1 Feb 2009

Yang Leilei, Wang Lijuan, Yang Xiao

Abstract excerpt

Follicle stem cells (SCs) residing in the bulge region of a hair follicle (HF) can give rise to multiple lineages during the hair cycle and wound healing. The activation and self-renewal of follicle SCs must be tightly regulated to maintain the HF and epidermal homeostasis. Here we show that, in young mice, disruption of epidermal Smad4, the common mediator of transforming growth factor-beta (TGF-beta) signaling,...

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Source

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Identifiers

PMID: 19073883
DOI: 10.1091/mbc.e08-07-0731
PMCID: PMC2633402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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