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Article

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis

1 Sept 2004

Abstract excerpt

Constitutive activation of signal transducer and activator of transcription 3 (Stat3) has been found in a wide spectrum of human malignancies. Here, we have assessed the effect of Stat3 deficiency on skin tumor development using the 2-stage chemical carcinogenesis model. The epidermis of Stat3-deficient mice showed a significantly reduced proliferative response following treatment with the tumor promoter...

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Identifiers

PMID: 15343391
DOI: 10.1172/jci21032

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Related research

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Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesisPMID 15343391Read ↗

Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesisSemantic proximity Read ↗

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