Article
Gsdma3 mutation causes bulge stem cell depletion and alopecia mediated by skin inflammation.
The American journal of pathology - 1 Feb 2012
Zhou Yue, Jiang Xuan, Gu Pengyu, Chen Weiqian, Zeng Xuesi, Gao Xiang
Abstract excerpt
Primary cicatricial alopecias (PCAs) are a group of permanent hair loss disorders, of which the pathogenesis is still poorly understood. The alopecia and excoriation (AE) mouse strain is a dominant mutant generated from ethyl nitrosourea mutagenesis. AE mice exhibit a progressive alopecia phenotype similar to that seen in PCAs, resulting from a point mutation in the gasdermin A3 gene. Mutant mice begin to show...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.