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Article

Phenotype of microsatellite-stable colorectal carcinomas with CpG island methylation.

The American journal of surgical pathology - 1 Apr 2005

Chirieac Lucian R, Shen Lanlan, Catalano Paul J, Issa Jean-Pierre, Hamilton Stanley R

Abstract excerpt

A distinctive pathway of colorectal carcinogenesis termed CpG island methylator phenotype is characterized by extensive DNA methylation in colorectal carcinoma (CRC) cells but not in nonneoplastic mucosa. Many CRCs with CpG island methylator phenotype have methylation of the hMLH1 mismatch repair gene and consequently have high levels of microsatellite instability (MSI-H). MSI-H confers distinctive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15767794
DOI: 10.1097/01.pas.0000155144.53047.7d

Genes

MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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