DNA Methylation, Field Effects, and Colorectal Cancer

Abstract excerpt

The concept of field effect was first introduced by Slaughter et al. ( 1 ) in 1953, when they studied the presence of histologically abnormal tissue surrounding oral squamous cell carcinoma. This concept, also called field defect or field cancerization, was proposed to explain the development of multiple primary tumors in the same organ and locally recurrent cancer. Field effects are considered to underlie the...

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