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Article

Aberrant Gene Promoter Methylation Associated with Sporadic Multiple Colorectal Cancer

19 Jan 2010

Abstract excerpt

BACKGROUND: Colorectal cancer (CRC) multiplicity has been mainly related to polyposis and non-polyposis hereditary syndromes. In sporadic CRC, aberrant gene promoter methylation has been shown to play a key role in carcinogenesis, although little is known about its involvement in multiplicity. To assess the effect of methylation in tumor multiplicity in sporadic CRC, hypermethylation of key tumor suppressor genes...

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PMID: 20098741
DOI: 10.1371/journal.pone.0008777

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