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Article

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.

The American journal of pathology - 1 Oct 2009

Welser Jennifer V, Rooney Jachinta E, Cohen Nicolette C, Gurpur Praveen B, Singer Cherie A, Evans Rebecca A, Haines Bryan A, Burkin Dean J

Abstract excerpt

The alpha7beta1 integrin, dystrophin, and utrophin glycoprotein complexes are the major laminin receptors in skeletal muscle. Loss of dystrophin causes Duchenne muscular dystrophy, a lethal muscle wasting disease. Duchenne muscular dystrophy-affected muscle exhibits increased expression of alpha7beta1 integrin and utrophin, which suggests that these laminin binding complexes may act as surrogates in the absence...

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Source

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Identifiers

PMID: 19729483
DOI: 10.2353/ajpath.2009.090052
PMCID: PMC2751551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.PMID 19729483Read ↗

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