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Article

Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic Mice

19 Mar 2001

Abstract excerpt

Muscle fibers attach to laminin in the basal lamina using two distinct mechanisms: the dystrophin glycoprotein complex and the alpha 7 beta 1 integrin. Defects in these linkage systems result in Duchenne muscular dystrophy (DMD), alpha 2 laminin congenital muscular dystrophy, sarcoglycan-related muscular dystrophy, and alpha 7 integrin congenital muscular dystrophy. Therefore, the molecular continuity between the...

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PMID: 11257121
DOI: 10.1083/jcb.152.6.1207

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Related research

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Research trail→

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Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic MicePMID 11257121Read ↗

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Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.Semantic proximity Read ↗

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The genetic and molecular basis of muscular dystrophy: roles of cell-matrix linkage in the pathogenesis.Semantic proximity Read ↗

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