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Article

Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.

Journal of cell science - 1 Aug 2004

Allikian Michael J, Hack Andrew A, Mewborn Stephanie, Mayer Ulrike, McNally Elizabeth M

Abstract excerpt

Disruption of the sarcoglycan complex leads to muscle membrane instability and muscular dystrophy in humans and mice. Through the dystrophin glycoprotein complex, sarcoglycan participates in connecting the internal cytoskeleton to the membrane and the extracellular matrix. Integrin alpha7beta1 is also a transmembrane protein of skeletal and cardiac muscle that similarly links the cytoskeleton to the extracellular...

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Source

Identifiers

PMID: 15252120
DOI: 10.1242/jcs.01234

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.PMID 15252120Read ↗

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Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.Semantic proximity Read ↗

Increasing α<sub>7</sub>β<sub>1</sub>-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionSemantic proximity Read ↗

Differential requirement for individual sarcoglycans and dystrophin in the assembly and function of the dystrophin-glycoprotein complex.Semantic proximity Read ↗

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