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Article

Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies.

1 Nov 1997

Abstract excerpt

The alpha7beta1 integrin is the primary laminin receptor on skeletal myoblasts and adult myofibers. It has distinct functions during muscle development and contributes to muscle structural integrity. We have studied this integrin in cases where expression of dystrophin or laminin are compromised. Immunofluorescence demonstrates an increase in alpha7beta1 in patients with Duchenne muscular dystrophy and in mdx...

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Identifiers

PMID: 9427295
DOI: 10.1242/jcs.110.22.2873

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies.PMID 9427295Read ↗

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Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophySemantic proximity Read ↗

Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic MiceSemantic proximity Read ↗

Increasing α<sub>7</sub>β<sub>1</sub>-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionSemantic proximity Read ↗

Laminin-111 protein therapy prevents muscle disease in the <i>mdx</i> mouse model for Duchenne muscular dystrophySemantic proximity Read ↗

Mutations in the integrin alpha7 gene cause congenital myopathy.Semantic proximity Read ↗

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.Semantic proximity Read ↗

Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.Semantic proximity Read ↗

Integrins (alpha7beta1) in muscle function and survival. Disrupted expression in merosin-deficient congenital muscular dystrophy.Semantic proximity Read ↗

Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.Semantic proximity Read ↗

Role for the α7β1 integrin in vascular development and integritySemantic proximity Read ↗

AAV-mediated overexpression of human α7 integrin leads to histological and functional improvement in dystrophic mice.Semantic proximity Read ↗

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