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Article

Increasing α<sub>7</sub>β<sub>1</sub>-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expression

29 Nov 2007

Abstract excerpt

The dystrophin-glycoprotein complex maintains the integrity of skeletal muscle by associating laminin in the extracellular matrix with the actin cytoskeleton. Several human muscular dystrophies arise from defects in the components of this complex. The alpha(7)beta(1)-integrin also binds laminin and links the extracellular matrix with the cytoskeleton. Enhancement of alpha(7)-integrin levels alleviates pathology...

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PMID: 18045857
DOI: 10.1152/ajpcell.00329.2007

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