Article
Loss of sarcospan exacerbates pathology in mdx mice, but does not affect utrophin amelioration of disease.
Human molecular genetics - 26 Apr 2021
Gibbs Elizabeth M, McCourt Jackie L, Shin Kara M, Hammond Katherine G, Marshall Jamie L, Crosbie Rachelle H
Abstract excerpt
The dystrophin-glycoprotein complex (DGC) is a membrane adhesion complex that provides structural stability at the sarcolemma by linking the myocyte's internal cytoskeleton and external extracellular matrix. In Duchenne muscular dystrophy (DMD), the absence of dystrophin leads to the loss of the DGC at the sarcolemma, resulting in sarcolemmal instability and progressive muscle damage. Utrophin (UTRN), an...
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