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Article

Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.

Human molecular genetics - 15 Oct 2012

Marshall Jamie L, Chou Eric, Oh Jennifer, Kwok Allan, Burkin Dean J, Crosbie-Watson Rachelle H

Abstract excerpt

Sarcospan (SSPN) is a core component of the major adhesion complexes in skeletal muscle, the dystrophin- and utrophin (Utr)-glycoprotein complexes (DGC and UGC). We performed a rigorous analysis of SSPN-null mice and discovered that loss of SSPN decreased DGC and UGC abundance, leading to impaire...

Read the complete abstract on PubMed

Topics

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Share to Antigens, CD
Share to Dystrophin
Share to Integrin alpha Chains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Skeletal

Share to Muscular Dystrophy, Duchenne

Share to Neoplasm Proteins

Share to Sarcolemma

Share to Utrophin

Source

Open in PubMed Open full text

Identifiers

PMID: 22798625
DOI: 10.1093/hmg/dds271
PMCID: PMC3459462

Genes

SSPN
DMD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22798625-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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