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Article

Severe muscular dystrophy in mice that lack dystrophin and α7 integrin

10 May 2006

Abstract excerpt

The dystrophin glycoprotein complex links laminin in the extracellular matrix to the cell cytoskeleton. Loss of dystrophin causes Duchenne muscular dystrophy, the most common human X-chromosome-linked genetic disease. The alpha7beta1 integrin is a second transmembrane laminin receptor expressed in skeletal muscle. Mutations in the alpha7 integrin gene cause congenital myopathy in humans and mice. The alpha7beta1...

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PMID: 16684813
DOI: 10.1242/jcs.02952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Severe muscular dystrophy in mice that lack dystrophin and α7 integrinPMID 16684813Read ↗

Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophySemantic proximity Read ↗

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Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic MiceSemantic proximity Read ↗

Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.Semantic proximity Read ↗

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.Semantic proximity Read ↗

Laminin-111 protein therapy prevents muscle disease in the <i>mdx</i> mouse model for Duchenne muscular dystrophySemantic proximity Read ↗

Increasing α<sub>7</sub>β<sub>1</sub>-integrin promotes muscle cell proliferation, adhesion, and resistance to apoptosis without changing gene expressionSemantic proximity Read ↗

Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.Semantic proximity Read ↗

Mutations in the integrin alpha7 gene cause congenital myopathy.Semantic proximity Read ↗

Integrin α7 Mutations Are Associated With Adult‐Onset Cardiac Dysfunction in Humans and MiceSemantic proximity Read ↗

Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.Semantic proximity Read ↗

Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.Semantic proximity Read ↗

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