Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy

13 Feb 2006

Abstract excerpt

Both the dystrophin-glycoprotein complex and alpha7beta1 integrin have critical roles in the maintenance of muscle integrity via the provision of mechanical links between muscle fibres and the basement membrane. Absence of either dystrophin or alpha7 integrin results in a muscular dystrophy. To clarify the role of alpha7 integrin and dystrophin in muscle development and function, we generated integrin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Exercise and Physiological Responses
Share to Muscle Physiology and Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16476707
DOI: 10.1093/hmg/ddl018

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Absence of α7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophyPMID 16476707Read ↗

Severe muscular dystrophy in mice that lack dystrophin and α7 integrinSemantic proximity Read ↗

Myotendinous junction defects and reduced force transmission in mice that lack alpha7 integrin and utrophin.Semantic proximity Read ↗

Genetic compensation for sarcoglycan loss by integrin alpha7beta1 in muscle.Semantic proximity Read ↗

Dystrophin and utrophin expression require sarcospan: loss of α7 integrin exacerbates a newly discovered muscle phenotype in sarcospan-null mice.Semantic proximity Read ↗

Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.Semantic proximity Read ↗

Enhanced Expression of the α7β1 Integrin Reduces Muscular Dystrophy and Restores Viability in Dystrophic MiceSemantic proximity Read ↗

Altered expression of the alpha7beta1 integrin in human and murine muscular dystrophies.Semantic proximity Read ↗

Loss of dystrophin and β-sarcoglycan significantly exacerbates the phenotype of laminin α2 chain-deficient animals.Semantic proximity Read ↗

Deletion of integrin-linked kinase from skeletal muscles of mice resembles muscular dystrophy due to alpha 7 beta 1-integrin deficiency.Semantic proximity Read ↗

The α7β1 integrin in muscle development and diseaseSemantic proximity Read ↗

Integrin α7 Mutations Are Associated With Adult‐Onset Cardiac Dysfunction in Humans and MiceSemantic proximity Read ↗

Combined deficiency of dystrophin and beta1 integrin in the cardiac myocyte causes myocardial dysfunction, fibrosis and calcification.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.