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Article

Expression of multidrug resistance-associated ABC transporters in B-CLL is independent of ZAP70 status.

Journal of cancer research and clinical oncology - 1 Mar 2010

Hoellein Alexander, Decker Thomas, Bogner Christian, Oelsner Madlen, Hauswald Stefanie, Peschel Christian, Keller Ulrich, Licht Thomas

Abstract excerpt

PURPOSE: To assess whether the poor prognosis of ZAP70-positive B-cell chronic lymphocytic leukemia (CLL) is associated with the overexpression of ABC transporter genes that are responsible for pleiotropic drug resistance. MATERIALS AND METHODS: The transcript level of ten drug transporters was analyzed using semiquantitative and quantitative RT-PCR in control hematopoietic cells, in 41 CLL patient samples and in...

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Share to ATP-Binding Cassette Transporters
Share to Blood Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Lymphoma, Non-Hodgkin

Share to Multidrug Resistance-Associated Proteins

Share to ZAP-70 Protein-Tyrosine Kinase

Source

Identifiers

PMID: 19727816
DOI: 10.1007/s00432-009-0670-9

Genes

ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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